Comparison of Soxhlet and Accelerated Solvent Extraction for Leachable and Extractable Analysis of Packing Material

نویسندگان

  • Hua Yang
  • Kate Comstock
  • Linda Lopez
چکیده

Introduction According to the regulations and guidelines set by regulatory agencies, including the U.S. Food and Drug Administration (US FDA),1 the European Medicines Agency (EMA),2 extractable and leachable information must be included in applications for medical devices and container closure systems packaging for human drugs and biologics. The specific applications include the New Drug Application (NDA), Abbreviated New Drug Application (ANDA) and Biologics License Application (BLA).

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparison of Hydrodistillation, Microwave Hydrodistillation and Solvent Free Microwave Methods in Analysis of the Essential Oils from Aerial Parts of Haplophyllum Robustum Bge. by GC/MS Method

The genus Haplophyllum, which belongs to the Rutaceae family, includes 18 species in Iran. In this study, after collecting plant material, botanical identification and suitable drying, the essential oils from aerial parts of Haplophyllum robustum Bge. were extracted by three different isolation techniques, conventional hydrodistillation (HD), microwave-assisted hydrodistillati...

متن کامل

Comparison of Hydrodistillation, Microwave Hydrodistillation and Solvent Free Microwave Methods in Analysis of the Essential Oils from Aerial Parts of Haplophyllum Robustum Bge. by GC/MS Method

The genus Haplophyllum, which belongs to the Rutaceae family, includes 18 species in Iran. In this study, after collecting plant material, botanical identification and suitable drying, the essential oils from aerial parts of Haplophyllum robustum Bge. were extracted by three different isolation techniques, conventional hydrodistillation (HD), microwave-assisted hydrodistillati...

متن کامل

The effects of solvent type and extraction method on phenolics content and antibacterial and antioxidant properties of Pennyroyal (Mentha pulegium L.) extract

Two of the major factors that should be considered in leaves extraction are the solvent type and extraction method. In the current study, the effects of two solvents (Ethanol and Methanol) and two extraction methods (soaking and soxhlet) on phenolics and flavonoid contents, antibacterial and antiradical properties of extracts were investigated in a factorial experiment based on completely rando...

متن کامل

Optimization and Comparison of Ultrasound-Assisted Extraction of Estragole from Tarragon Leaves with Hydro-Distillation Method

A comparative study of ultrasound-assisted extraction (UAE) and hydro-distillation was performed for fast extraction of estragole from tarragon (Artemisia dracunculus L.) dried leaves. Several influential parameters of the UAE procedure in the extraction of estragole (type of solvent, extraction cycles, solvent to material ratio, irradiation time and particle size) were investigated an...

متن کامل

Comparison of soxhlet, ultrasound-assisted and pressurized liquid extraction of terpenes, fatty acids and Vitamin E from Piper gaudichaudianum Kunth.

This paper describes a comparative study of extraction methods of terpenes (terpenic alcohols and phytosterols), fatty acids and Vitamin E from leaves of Piper gaudichaudianum Kunth. The analysis of extracts was done by gas chromatography with mass spectrometric detection. The identification and quantification was made by co-injections of the extract with certified standards. The use of pressur...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016